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Sellel leheküljel leiad palju näiteid tõlgitud lauseid, mis sisaldavad "annuse suurendamise" pärit eesti et Inglise.
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- However, if acute moderate to severe adverse reactions such as hypotension, rigors, fever, shortness of breath, chills, rashes and bronchospasm some of which may be due to cytokine release occur at either the 3 mg or 10 mg dose levels, then those doses should be repeated daily until they are well tolerated before further dose escalation is attempted see section 4.4 .
- No adjustments to the recommended dose escalation guidelines for lamotrigine should be necessary solely based on the use of hormonal contraceptives, but the maintenance dose of lamotrigine will need to be increased or decreased in most cases when starting or stopping hormonal contraceptives see section 4.2 .
- Safety data in first line B CLL patients are based on adverse reactions that occurred on study in 147 patients enrolled in a randomized, controlled study of MabCampath as a single agent administered at a dose of 30 mg intravenously three times weekly for up to 12 weeks, inclusive of dose escalation period.
- Prescribers should assess the need for escalation to maintenance dose when restarting Lamictal in patients who have discontinued Lamictal for any reason, since the risk of serious rash is associated with high initial doses and exceeding the recommended dose escalation for lamotrigine see section 4.4 .
- In clinical trials of adult CML and Ph ALL patients, dose escalation to 140 mg once daily chronic phase CML or 100 mg twice daily advanced phase CML or Ph ALL was allowed in patients who did not achieve a haematologic or cytogenetic response at the recommended starting dose.
- The safety and efficacy of clofarabine were evaluated in a phase I, open label, non comparative, dose escalation study in 25 paediatric patients with relapsed or refractory leukaemia 17 ALL 8 AML who had failed standard therapy or for whom no other therapy existed.
- In an open label non comparative dose escalation study in 18 paediatric patients 4 to 19 years with leukaemic meningitis or neoplastic meningitis due to primary brain tumour, an intrathecal dose of 35 mg was identified as the maximum tolerated dose.
- In an open label extension study, for patients who dose escalated from 40 mg every other week to 40 mg weekly due to a PASI response below 50 and were evaluated at 12 weeks after dose escalation, 59 243 24.3 of patients regained PASI 75 response.
- Patients should be premedicated with oral or intravenous steroids, an appropriate antihistamine and analgesic 30 60 minutes prior to each MabCampath infusion during dose escalation and as clinically indicated thereafter see section 4.4 .
- In patients taking medicinal products where the pharmacokinetic interaction with lamotrigine is currently not known see section 4.5 , the dose escalation as recommended for lamotrigine with concurrent valproate, should be used.
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